刘向荣

1977年生，北京协和医学院内科学博士，副教授，硕导。主要研究方向：卒中神经保护及药物临床前评价。

刘向荣先后在美国匹兹堡大学医学中心和杜克大学医学院接收科研训练，主要从事卒中机制研究并探索新的神经保护药物。先后主持国家级课题3项，省部级课题2项。在Stroke等杂志发表英文论文34篇，核心期刊论文24篇。

现任中国老年学学会老年医学委员会青年委员会副主任委员，中华预防医学会老年病预防专业委员会委员，中国老年医学学会脑血管病分会青年委员，北京神经内科学会专业委员会委员，国家自然科学基金通讯评审专家。2017年获得由美国心脏学会和中风学会联合颁发的“卒中进步与创新奖”。

• 2018.1-今  首都医科大学附属北京天坛医院国家神经系统疾病临床研究中心  副教授/副研究员
• 2017.9-2017.12  美国杜克大学医学院神经病学系  访问学者
• 2016.7-2017.8  首都医科大学宣武医院中美神经科学研究室  副教授/副研究员
• 2015.12-2016.6  首都医科大学宣武医院脑血管病研究室  副教授
• 2014.11-2016.6  首都医科大学宣武医院脑血管病研究室  副研究员
• 2013.7-2014.10  美国匹兹堡大学医学中心神经病学系  访问学者
• 2010.8-2014.10  首都医科大学宣武医院脑血管病研究室  助理研究员
• 2008.8-2010.7  首都医科大学宣武医院神经外科  博士后
• 2003.9-2008.7  北京协和医学院血液学研究所  内科学博士学位
• 2000.8-2003.7  潍坊医学院附属医院内科  住院医师
• 1995.8-2000.7  第二军医大学军医系  临床医学学士学位

• 2017 美国心脏学会和中风学会联合颁发的“卒中进步与创新奖”
• 2013 第26届国际脑血流与脑代谢会议青年学者奖

1. Xiangrong Liu, Shaohong Wen, Feng Yan, Kuan Liu, Liqiang Liu, Lei Wang, Shangfeng Zhao, Xunming Ji. Salidroside provides neuroprotection by modulating microglial polarization after cerebral ischemia. J Neuroinflammation. 2018;15(1):39.
2. Xiangrong Liu, Shaohong Wen, Shunying Zhao, Feng Yan, Shangfeng Zhao, Di Wu, Xunming Ji. Mild Therapeutic Hypothermia Protects the Brain from Ischemia/Reperfusion Injury through Upregulation of iASPP. Aging Dis. 2018: 9(2). http://www.aginganddisease.org/EN/10.14336/AD.2017.0703. Epub on line. 
3. Xiangrong Liu, Jun Kang, Si Sun, Yumin Luo, Xunming Ji, Xianwei Zeng, Shangfeng Zhao. MiR-124 targeting iASPP is aberrantly expressed in astrocytoma and regulates malignant glioma cell migration and growth. Mol Med Rep. 2018; 17: 1970-1978.
4. Xiangrong Liu, Di Wu, Shaohong Wen, Shunying Zhao, Ao Xia, Fang Li, Xunming Ji. Mild therapeutic hypothermia protects against cerebral ischemia/reperfusion by inhibiting miR-15b expression in rats. Brain Circ. 2017;3:209-216.
5. Xiangrong Liu, Jia Liu, Shangfeng Zhao, Haiyue Zhang, Wei Cai, Xunming Ji, Rehana Leak, Yanqin Gao, Jun Chen, Xiaoming Hu. Interleukin-4 is Essential for Microglia/Macrophage M2 Polarization and Long-term Recovery after Cerebral Ischemia. Stroke. 2016;47(2):498-504.
6. Xiangrong Liu, Jun Kang, Fang Liu, Shaohong Wen, Xianwei Zeng, Kuan Liu, Yumin Luo, Xunming Ji, Shangfeng Zhao. Overexpression of iASPP-SV in glioma is associated with poor prognosis by promoting cell viability and antagonizing apoptosis. Tumor Biology. 2016;37(5):6323-6330.
7. Xiangrong Liu, Shangfeng Zhao, Fang Liu, Jun Kang, Ao Xiao, Fang Li, Chencheng Zhang, Feng Yan, Haiping Zhao, Mei Luo, Yumin Luo, Xunmin Ji. Remote ischemic postconditioning alleviates cerebral ischemic injury by attenuating endoplasmic reticulum stress-mediated apoptosis. Transl Stroke Res. 2014;5(6):692-700.
8. Xiangrong Liu, Fang Li, Shangfeng Zhao, Yumin Luo, Jun Kang, Haiping Zhao, Feng Yan, Sijie Li, Xunming Ji. MiRNA-124-mediated regulation of inhibitory member of apoptosis stimulating protein of p53 family in experimental stroke. Stroke. 2013;44(7):1973-1980.
9. Xiang-Rong Liu, Mei Luo, Feng Yan, Chen-Cheng Zhang, Si-Jie Li, Hai-Ping Zhao, Xun-Ming Ji, Yu-Min Luo. Ischemic postconditioning diminishes matrix metalloproteinase 9 expression and attenuates loss of the extracellular matrix proteins in rats following middle cerebral artery occlusion and reperfusion. CNS Neuroscience & Therapeutics. 2012; 18(10):855-863.
10. Xiangrong Liu, Lei Wang, Shangfeng Zhao, Xunming Ji, Yumin Luo, Feng Ling. β-catenin overexpression in malignant glioma and its role in proliferation and apoptosis in glioblastma cells. Med Oncol. 2011; 28(2):608-614.
11. Xiangrong Liu, Qing Zhang, Dong-er Zhang, Chunlin Zhou, Haiyan Xing, Zheng Tian, Qing Rao, Min Wang, Jianxiang Wang. Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis. Leukemia. 2009; 23(4):739-745.
12. Zongjian Liu, Yuanyuan Ran, Shuo Huang, Shaohong Wen, Wenxiu Zhang, Xiangrong Liu, Zhili Ji, Xiaokun Geng, Xunming Ji, Huishan Du, Rehana K. Leak, Xiaoming Hu. Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization. Front Aging Neurosci. 2017;9:233.
13. Di Wu, Jingfei Shi, Omar Elmadhoun, Yunxia Duan, Hong An, Jun Zhang, Xiaoduo He, Ran Meng, Xiangrong Liu, Xunming Ji, Yuchuan Ding. Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat. Brain Res. 2017;1671:18-25.
14. Yejie Shi, Lili Zhang, Hongjian Pu, Leiei Mao, Xiaoming Hu, Xiaoyan Jiang, Na Xu, R. Anne Stetler, Feng Zhang, Xiangrong Liu, Rehana K. Leak, Richard F. Keep, Xunming Ji, Chen Jun. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury. Nat Commun. 2016;7:10523.
15. Ziping Han, Xiangrong Liu, Yumin Luo, Xunming Ji. Therapeutic hypothermia for stroke: Where to go? Exp Neurol. 2015;272:67-77.
16. Ping Liu, Haiping Zhao, Rongliang Wang, Wang P, Zhen Tao, Li Gao, Feng Yan, Xiangrong Liu, Shun Yu, Xunming Ji, Yumin Luo. MicroRNA-424 protects against focal cerebral ischemia and reperfusion injury in mice by suppressing oxidative stress. Stroke. 2015;46(2):513-519.
17. Rongliang Wang, Xiaoning Wu, Jia Liang, Zhifeng Qi, Xiangrong Liu, Lianqiu Min, Xunming Ji, Yumin Luo, Haiping Zhao. Intra-artery infusion of recombinant human erythropoietin reduces blood–brain barrier disruption in rats following cerebral ischemia and reperfusion. Int J Neurosci. 2015;125(9):693-702.
18. Haiping Zhao, Rongliang Wang, Xiaoning Wu, Jia Liang, Zhifeng Qi, Xiangrong Liu, Lianqiu Min, Xunming Ji, Yumin Luo. Erythropoietin delivered via intra-arterial infusion reduces endoplasmic reticulum stress in brain microvessels of rats following cerebral ischemia and reperfusion. J Neuroimmune Pharmacol. 2015;10(1):153-161.
19. Haiping Zhao, Rongliang Wang, Zhen Tao, Feng Yan, Li Gao, Xiangrong Liu, Ningqun Wang, Lianqiu Min, Yujie Jia, Yongmei Zhao, Xunming Ji, Yumin Luo. Activation of T-LAK-cell-originated protein kinase-mediated antioxidation protects against focal cerebral ischemia-reperfusion injury. FEBS J. 2014;281(19):4411-4420.
20. Haiping Zhao, Rongliang Wang, Zhen Tao, Li Gao, Feng Yan, Zhi Gao, Xiangrong Liu, Xunming Ji, Yumin Luo. Ischemic postconditioning relieves cerebral ischemia and reperfusion injury through activating T-LAK cell-originated protein kinase/protein kinase B pathway in rats. Stroke. 2014;45(8):2417-2424.
21. Ping Liu, Xiaolei Liu, Anthony Kian-Fong Liou, Juan Xing, Zheng Jing, Xunming Ji, Xiangrong Liu, Haiping Zhao, Feng Yan, Jun Chen, Guodong Cao , Yumin Luo. The neuroprotective mechanism of erythropoietin-TAT fusion protein against neurodegeneration from ischemic brain injury. CNS Neurol Disord Drug Targets. 2014;13(8):1465-1474.
22. Peiying Li, Leilei Mao, Xiangrong Liu, Yu Gan, Jing Zheng, Angus W. Thomson, Yanqin Gao, Jun Chen, Xiaoming Hu. Essential role of program death 1-ligand 1 in regulatory T-cell-afforded protection against blood-brain barrier damage after stroke. Stroke. 2014;45(3):857-864.
23. Haiping Zhao, Yumin Luo, Xiangrong Liu, Rongliang Wang, Feng Yan, Xiangrong Liu, Sijie Li,  Rehana K. Leak, Xunming Ji. Ischemic post-conditioning partially reverses cell cycle reactivity following ischemia/reperfusion injury: a genome-wide survey. CNS Neurol Disord Drug Targets. 2013;12(3):350-359.
24. Rehana K. Leak, Lili Zhang, Yumin Luo, Peiying Li, Haiping Zhao, Xiangrong Liu, Feng Ling, Jianping Jia, Jun Chen, Xunming Ji. Peroxiredoxin 2 battles poly(ADP-ribose) polymerase 1- and p53-dependent prodeath pathways after ischemic injury. Stroke. 2013;44(4):1124-34.
25. Haiping Zhao, Jun Wang, Li Gao, Rongliang Wang, Xiangrong Liu, Zhi Gao, Zhen Tao, Changmin Xu, Juexian Song, Xunming Ji, Yuming Luo. MiRNA-424 protects against permanent focal cerebral ischemia injury in mice involving suppressing microglia activation. Stroke. 2013; 44(6):1706-1713.
26. Yu Gan, Xunming Ji, Xiaoming Hu, Yumin Luo, Lili Zhang, Peiying Li, Xiangrong Liu, Feng Yan, Peter Vosler, Yanqin Gao, R. Anne Stetler, Jun Chen. FenAntioxidants & Redox Signaling. Transgenic overexpression of peroxiredoxin-2 attenuates ischemic neuronal injury via suppression of a redox-sensitive pro-death signaling pathway. Antioxid Redox Signal. 2012, 17(5): 719-732.
27. Ying Zhang, Xiangrong Liu, Feng Yan, Lianqiu Min, Xunming Ji, Yumin Luo. Protective effects of remote ischemic preconditioning in rat hindlimb on ischemia-reperfusion injury. Neural Regen Res. 2012; 7(8):583-587.
28. Zhi-Feng Qi, Yu-Min Luo, Xiang-Rong Liu, Rong-Liang Wang, Hai-Ping Zhao, Feng Yan, Zhao-Jing Song, Mei Luo, Xun-Ming Ji. AKT/GSK3β-Dependent Autophagy Contributes to the Neuroprotection of Limb Remote Ischemic Postconditioning in the Transient Cerebral Ischemic Rat Model. CNS Neurosci Ther. 2012;18(12):965-973.
29. Shangfeng Zhao, Jjdi Fu, Xiangrong Liu, Tony Wang, Jialiang Zhang, Yuanli Zhao. Activation of Akt/GSK-3beta/beta-catenin signaling pathway is involved in survival of neurons after traumatic brain injury in rats. Neurol Res. 2012; 34(4):400-407.
30. Yoshihiro Murata,  Norio Fujiwara, Ji Hae Seo, Feng Yan, Xiangrong Liu, Yasukazu Terasaki, Yumin Luo, Ken Arai, Xunming Ji, Eng H Lo. Delayed Inhibition of c-Jun N-Terminal Kinase Worsens Outcomes after Focal Cerebral Ischemia. J Neurosci. 2012;32(24):8112-8115.
31. Xiaokun Geng, Changhong Ren, Tony Wang, Paul Fu, Yumin Luo, Xiangrong Liu, Feng Yan, Feng Ling, Jianping Jia, Huishan Du, Xunming Ji, Yuchuan Ding. Effect of remote ischemic postconditioning on an intracerebral hemorrhage stroke model in rats. Neurol Res. 2012;34(2):143-148.
32. Sha Dang, Xiangrong Liu, Paul Fu, Wei Gong, Feng Yan, Pingxin Han, Yuchuan Ding, Xunming Ji, Yumin Luo. Neuroprotection by local intra-arterial infusion of erythropoietin after focal cerebral ischemia in rats. Neurol Res. 2011; 33 (5): 520-528.
33. Hui Wei, Xiangrong Liu, Xiujuan Xiong, Yang Wang, Qing Rao, Min Wang, Jianxiang Wang. AML1-ETO interacts with Sp1 and antagonizes Sp1 transactivity through RUNT domain. FEBS lett. 2008; 582(15):2167-2172.
34. Wenjuan Yu, Qing Rao, Min Wang, Zheng Tian, Dong Lin, Xiangrong Liu, Jianxiang Wang. The Hsp90 inhibitor 17-allylamide-17-demethoxygeldanamycin induces apoptosis and differentiation of Kasumi-1 harboring the Asn822Lys KIT mutation and down-regulates KIT protein level. Leuk Res. 2006; 30(5):575-582.
35. 刘宽，曾现伟，吉训明，刘向荣. p53凋亡刺激蛋白家族对自噬调控作用的研究进展. 临床与病理杂志. 2016;36(6):859-863.
36. 王磊，曾现伟，吉训明，刘向荣. 毛柳甙对缺血性脑卒中保护作用机制的研究进展. 中国脑血管病杂志. 2017;14 (4):208-211.
37. 温少红，吴迪，刘向荣，吉训明. 缺血性脑血管病后小胶质细胞极化的研究进展. 中国脑血管病杂志. 2017;14 (03): 159-163.
38. 刘向荣，罗玉敏，闫峰，张陈诚，吉训明. iASPP在大鼠脑缺血再灌注中的表达及其意义. 中国卒中杂志. 2010;5(3):185-189.
39. 刘向荣，赵尚峰，吉训明，罗玉敏，韩平欣，凌锋. siRNA沉默β-catenin对人胶质瘤细胞系SHG44增殖和凋亡的作用. 中华肿瘤防治杂志. 2010; 17(6):420-422.
40. 刘向荣，邢海燕，田征，唐克晶，饶青，王敏，王建祥. 全反式维甲酸处理NB4细胞微RNA表达谱分析. 中华血液学杂志. 2008;9(8):501-503.
41. 刘向荣，王建祥. WNT信号传导途径在造血干细胞自我更新中的作用。国外医学移植与血液净化分册. 2004;3(5):37-40.
42. 闫峰，刘向荣，赵海苹，王荣亮，吉训明，赵咏梅，陶真，罗玉敏. 不同性别大鼠局灶性脑缺血脑血流及梗死体积的变化. 首都医科大学学报. 2013; 34(1):64-68.
43. 李芳，刘向荣，闫峰，张陈诚，罗玉敏，方伯言，吉训明. 局部亚低温对大鼠脑缺血再灌注基质金属蛋白酶9及细胞外基质蛋白表达的影响. 首都医科大学学报. 2013;34(1):58-63.
44. 李芳，刘向荣，罗玉敏，吉训明. microRNA-124与神经系统疾病. 中华神经科杂志. 2013;46(1): 53-55.
45. 夏傲，刘向荣，罗玉敏，吉训明. 低温对脑缺血后血－脑屏障完整性保护机制的研究进展. 中国脑血管病杂志. 2012;9(8):445-448.
46. 闫峰，刘向荣，赵海苹，王荣亮，吉训明，罗玫，罗玉敏. 长期远隔后适应对脑缺血再灌注大鼠脑组织神经中丝200表达的影响. 首都医科大学学报. 2012;33(6)766-770.
47. 闫峰，刘向荣，张营，张陈诚，吉训明，罗玉敏. 远隔后适应对大鼠脑组织中淀粉样前体蛋白表达的影响. 首都医科大学学报. 2011; 32(4):489-493.
48. 张营，刘向荣，吉训明，闫峰，张陈诚，罗玉敏. 脑缺血-再灌注损伤对大鼠脑组织髓磷脂相关糖蛋白表达的影响. 中国脑血管病杂志. 2010;7(11):588-591.
49. 赵尚峰，刘向荣，储波，张懋植，王磊. β-catenin在胶质瘤中的表达及其意义. 中国卫生检验杂志. 2010;20(1):15-17.
50. 魏辉，刘向荣，刘航，饶青，王敏，王建祥. AML1-ETO对p21WAF1/CIP1 基因启动子转录活性作用的研究. 中华血液学杂志. 2007;28(8):545-548.
51. 魏辉，刘向荣，林冬，饶青，林跃辉，王敏，王建祥. 组蛋白脱乙酰化酶抑制剂通过上调p21WAF1/CIP1抑制白血病细胞系的细胞周期. 中华血液学杂志. 2006;27(5):298-301.
52. 邢海燕，张新伟，刘向荣，唐克晶，田征，刁世勇，饶青，王敏，王建祥. 癌蛋白iASPP对大鼠骨髓细胞增生促进作用研究. 白血病·淋巴瘤. 2007，16(5):324-326.
53. 刘小蒙，吉训明，段丽芬，刘向荣，赵海苹，闫峰，王荣亮，罗玉敏. 脑梗死溶栓前后血浆生长因子和低氧诱导因子含量的变化.中华老年心脑血管病杂志. 2012，14(10):1071-1073.
54. 李敏，刘航，徐智芳，刘向荣，王洋，饶青，王建祥，王敏. 白血病细胞系中抑癌基因PTEN启动子区甲基化状态检测及其去甲基化研究. 中华血液学杂志. 2008, 29(5):289-292.
55. 吴隆飞，吴迪，刘向荣，赵文博，丁玉川，吉训明. 脑动脉选择性亚低温治疗缺血性卒中的研究进展. 中国脑血管病杂志. 2017;14(03):155-158.
56. 马春，李淑婷，罗玉敏，陈健，刘向荣，吉训明. 远程缺血预适应训练治疗基底动脉支架术后残余眩晕患者一例. 中华神经科杂志. 2011;44(8)：580-582.
57. 卢旭霞，牛小媛，罗玉敏，闫峰，刘向荣，吉训明. 远程缺血后适应对大鼠脑缺血/再灌注损伤的影响. 中国脑血管病室杂志. 2010,7(3):139-142.
58. 俞文娟，饶青，王敏，田征，刘向荣，林冬，王建祥. 热休克蛋白90抑制剂诱导Kasumi-1细胞凋亡和分化的机制探讨. 中华血液学杂志. 2005;26(12):728-731.

• 中国老年学学会老年医学委员会青年委员会 副主任委员
• 中华预防医学会老年病预防专业委员会 委员
• 中国老年医学学会脑血管病分会 青年委员
• 北京神经内科学会专业委员会 委员
• Cancer letters同行评议专家
• International Journal of Molecular Medicine同行评议专家
• 国家自然科学基金通讯评审专家

1. 国家自然科学基金（面上项目）

项目名称：   miR-124靶向iASPP在脑缺血小胶质细胞极化表型中的作用及机制研究

项目编号：   81471209

起止时间：   2015.01~2018.12

项目经费：   70万元

2. 国家自然科学基金（应急管理项目）

课题名称：   毛柳甙干预小胶质细胞极化在脑缺血白质损伤中的远期保护作用及机制研究

课题编号：   81641055

起止时间：   2017.01~2017.12

课题经费：   10万元

3. 国家自然科学基金（青年项目）

课题名称：   凋亡抑制因子iASPP在缺血性脑损伤中的作用及机制研究

课题编号：   81000504

起止时间      2011.01~2013.12

课题经费      20万元

4. 北京自然科学基金面上项目：

课题名称：   miR-124在早期缺血性脑损伤中的作用及其靶点鉴定

课题编号：   7132112

起止时间：   2013.01~2015.12

课题经费：   14万元

5. 中国博士后科学基金资助项目

课题名称：   神经生长因子受体TrkA在亚低温治疗脑缺血中作用机制的研究

课题编号：   20080440423

起止时间：   2008.12~2010.07

课题经费：   3万元